Microarray Publications Database
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Title: | Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia |
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List of authors: | van Delft, FW; Horsley, S; Colman, S; Anderson, K; Bateman, C; Kempski, H; Zuna, J; Eckert, C; Saha, V; Kearney, L; Ford, A; Greaves, M |
Reference: | Blood 2011. Jun 9;117(23):6247-54 |
Year of Publication: | 2011 |
Abstract: | B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1) fusion has an overall good prognosis, but relapses occur, usually after cessation of treatment and occasionally many years later. We have investigated the clonal origins of relapse by comparing the profiles of genomewide copy number alterations at presentation in 21 patients with those in matched relapse (12-119 months). We identified, in total, 159 copy number alterations at presentation and 231 at relapse (excluding Ig/TCR). Deletions of CDKN2A/B or CCNC (6q16.2-3) or both increased from 38% at presentation to 76% in relapse, suggesting that cell-cycle deregulation contributed to emergence of relapse. A novel observation was recurrent gain of chromosome 16 (2 patients at presentation, 4 at relapse) and deletion of plasmocytoma variant translocation 1 in 3 patients. The data indicate that, irrespective of time to relapse, the relapse clone was derived from either a major or minor clone at presentation. Backtracking analysis by FISH identified a minor subclone at diagnosis whose genotype matched that observed in relapse ¿ 10 years later. These data indicate subclonal diversity at diagnosis, providing a variable basis for intraclonal origins of relapse and extended periods (years) of dormancy, possibly by quiescence, for stem cells in ETV6-RUNX1(+) acute lymphoblastic leukemia. |
PMID: | 21482711 |
Supplementary Data: |
SNP Genotype Data The SNP Genotype Data is listed below. The following key deciphers the file names. Key: NSP = Affymetrix 250K Nsp1 array STY = Affymetrix 250K Sty1 array
10P_STY 10R1_NSP 10R1_STY 10R2_NSP 10R2_STY 10Rem_NSP 10Rem_STY 11P_NSP 11P_STY 11Rem_NSP 11Rem_STY 11R_NSP 11R_STY 13P_NSP 13P_STY 13Rem_NSP 13Rem_STY 13R_NSP 13R_STY 14P_NSP 14P_STY 14Rem_NSP 14Rem_STY 14R_NSP 14R_STY 15P_NSP 15P_STY 15Rem_NSP 15Rem_STY 15R_NSP 15R_STY 16P_NSP 16P_STY 16Rem_NSP 16Rem_STY 16R_NSP 16R_STY 17P_NSP 17P_STY 17Rem_NSP 17Rem_STY 17R_NSP 17R_STY 18P_STY 18Rem_NSP 18Rem_STY 18R_NSP 18R_STY 19P_NSP 19P_STY 19Rem_NSP 19Rem_STY 19R_NSP 19R_STY 20P_NSP 20P_STY 20Rem_NSP 20Rem_STY 20R_NSP 20R_STY 21P_NSP 21P_STY 21Rem_NSP 21Rem_STY 21R_NSP 21R_STY 22P_NSP 22P_STY 22Rem_NSP 22Rem_STY 22R_NSP 22R_STY 23P_NSP 23P_STY 23Rem_NSP 23Rem_STY 23R_NSP 23R_STY 25P_NSP 25P_STY 25Rem_NSP 25Rem_STY 25R_NSP 25R_STY 26P_NSP 26P_STY 26Rem_NSP 26Rem_STY 26R_NSP 26R_STY 27P_NSP 27P_STY 27Rem_STY 27Rem_NSP 27R_NSP 27R_STY 2P_NSP 2P_STY 2R_NSP 2R_STY 6P_NSP 6P_STY 6R1_NSP 6R1_STY 6R2_NSP 6R2_STY 6Rem_NSP 6Rem_STY 7P_NSP 7P_STY 7Rem_NSP 7Rem_STY 7R_NSP 7R_STY 8P_NSP 8P_STY 8Rem_NSP 8Rem_STY 8R_NSP 8R_STY 9P_NSP 9P_STY 9Rem_NSP 9Rem_STY 9R_NSP 9R_STY |