Microarray Publications Database
Supplementary Data Table 5b
HepG2 EASE results (p<0.05).
Time and concentration down-regulated genes
Biological Process | List Hits | List Total | Population Hits | Population Total | One-tailed Fisher exact probability | Gene Symbol |
---|---|---|---|---|---|---|
nucleosome assembly | 3 | 26 | 30 | 6663 | 2.0E-04 | HIST1H2BJ; HIST1H2BN; HIST1H3D |
establishment and/or maintenance of chromatin architecture | 4 | 26 | 96 | 6663 | 4.7E-04 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
DNA packaging | 4 | 26 | 104 | 6663 | 6.4E-04 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
chromosome organization and biogenesis (sensu Eukarya) | 4 | 26 | 116 | 6663 | 9.7E-04 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
nuclear organization and biogenesis | 4 | 26 | 118 | 6663 | 1.0E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
chromatin assembly/disassembly | 3 | 26 | 53 | 6663 | 1.1E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D |
complement activation\, classical pathway | 2 | 26 | 26 | 6663 | 4.5E-03 | APOH; C1QG |
complement activation | 2 | 26 | 30 | 6663 | 6.0E-03 | APOH; C1QG |
vacuolar protein catabolism | 1 | 26 | 2 | 6663 | 7.8E-03 | CPA2 |
DNA metabolism | 5 | 26 | 344 | 6663 | 9.5E-03 | CTGF; HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
blood coagulation | 2 | 26 | 61 | 6663 | 2.3E-02 | FGG; THBS1 |
transcription from Pol II promoter | 4 | 26 | 298 | 6663 | 2.7E-02 | MAFG; TAF6L; TCEB3; TIF1 |
hemostasis | 2 | 26 | 66 | 6663 | 2.7E-02 | FGG; THBS1 |
morphogenesis | 6 | 26 | 653 | 6663 | 3.6E-02 | CTGF; DPYSL2; GPC3; HUMMLC2B; RPS6KA3; THBS1 |
humoral defense mechanism (sensu Vertebrata) | 2 | 26 | 78 | 6663 | 3.7E-02 | APOH; C1QG |
FGF receptor signaling pathway | 1 | 26 | 10 | 6663 | 3.8E-02 | CTGF |
skeletal development | 2 | 26 | 89 | 6663 | 4.7E-02 | CTGF; RPS6KA3 |
Time and concentration up-regulated genes
Biological Process | List Hits | List Total | Population Hits | Population Total | One-tailed Fisher exact probability | Gene Symbol |
---|---|---|---|---|---|---|
nucleosome assembly | 3 | 34 | 30 | 6663 | 4.5E-04 | HIST1H2BJ; HIST1H2BN; HIST1H3D |
prostaglandin metabolism | 2 | 34 | 8 | 6663 | 6.9E-04 | AKR1C3; MGST1 |
prostanoid metabolism | 2 | 34 | 8 | 6663 | 6.9E-04 | AKR1C3; MGST1 |
establishment and/or maintenance of chromatin architecture | 4 | 34 | 96 | 6663 | 1.3E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
DNA packaging | 4 | 34 | 104 | 6663 | 1.8E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
chromatin assembly/disassembly | 3 | 34 | 53 | 6663 | 2.4E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D |
chromosome organization and biogenesis (sensu Eukarya) | 4 | 34 | 116 | 6663 | 2.7E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
nuclear organization and biogenesis | 4 | 34 | 118 | 6663 | 2.9E-03 | HIST1H2BJ; HIST1H2BN; HIST1H3D; TAF6L |
icosanoid metabolism | 2 | 34 | 17 | 6663 | 3.3E-03 | AKR1C3; MGST1 |
blood coagulation | 3 | 34 | 61 | 6663 | 3.6E-03 | ITGA2; SERPINE1; THBS1 |
hemostasis | 3 | 34 | 66 | 6663 | 4.5E-03 | ITGA2; SERPINE1; THBS1 |
glucuronate metabolism | 1 | 34 | 1 | 6663 | >5.1E-03 | UGDH |
uronic acid metabolism | 1 | 34 | 1 | 6663 | 5.1E-03 | UGDH |
UDP-glucuronate biosynthesis | 1 | 34 | 1 | 6663 | 5.1E-03 | UGDH |
glucuronate biosynthesis | 1 | 34 | 1 | 6663 | 5.1E-03 | UGDH |
UDP-glucuronate metabolism | 1 | 34 | 1 | 6663 | 5.1E-03 | UGDH |
obsolete biological process | 6 | 34 | 324 | 6663 | 5.3E-03 | BIRC5; CDKN1A; HIST1H3D; IER3; JAG1; TXNRD1 |
DNA metabolism | 6 | 34 | 344 | 6663 | 7.1E-03 | CRY1; HIST1H2BJ; HIST1H2BN; HIST1H3D; PCNA; TAF6L |
xenobiotic metabolism | 2 | 34 | 29 | 6663 | 9.4E-03 | AKR1C1; NQO1 |
response to xenobiotic stimulus | 2 | 34 | 30 | 6663 | 1.0E-02 | AKR1C1; NQO1 |
keratinocyte differentiation | 1 | 34 | 2 | 6663 | 1.0E-02 | JAG1 |
endothelial cell differentiation | 1 | 34 | 2 | 6663 | 1.0E-02 | JAG1 |
UDP-glucose metabolism | 1 | 34 | 2 | 6663 | 1.0E-02 | UGDH |
myoblast differentiation | 1 | 34 | 2 | 6663 | 1.0E-02 | JAG1 |
cell growth and/or maintenance | 18 | 34 | 2180 | 6663 | 1.1E-02 | AKAP12; AKR1C3; APOC1; APOC2; BIRC5; CDKN1A; GEM; GSN; HIST1; H2BJ; HIST1H2BN; HIST1H3D; IER3; IGFBP1; JAG1; K-ALPHA-1; PCNA; RPS27L; TAF6L |
G2/M transition of mitotic cell cycle | 2 | 34 | 35 | 6663 | 1.4E-02 | BIRC5; CDKN1A |
cellular process | 25 | 34 | 3568 | 6663 | 1.4E-02 | AKAP12; AKR1C3; APOC1; APOC2; BIRC5; CCL20; CDKN1A; GEM; GSN; HIST1H2BJ; HIST1H2BN; HIST1H3D; IER3; IGFBP1; ITGA2; ITPKB; JAG1; K-ALPHA-1; NELL1; NQO1; PCNA; RPS27L; TAF6L; THBS1; TXNRD1 |
cell organization and biogenesis | 6 | 34 | 399 | 6663 | 1.4E-02 | GSN; HIST1H2BJ; HIST1H2BN; HIST1H3D; K-ALPHA-1; TAF6L |
lipid transport | 2 | 34 | 37 | 6663 | 1.5E-02 | APOC1; APOC2 |
cysteine metabolism | 1 | 34 | 3 | 6663 | 1.5E-02 | GCLM |
embryogenesis and morphogenesis | 2 | 34 | 46 | 6663 | 2.3E-02 | HIST1H3D; IER3 |
synaptic transmission\, cholinergic | 1 | 34 | 5 | 6663 | 2.5E-02 | NQO1 |
actin filament polymerization | 1 | 34 | 5 | 6663 | 2.5E-02 | GSN |
oncogenesis | 2 | 34 | 50 | 6663 | 2.7E-02 | BIRC5; CDKN1A |
response to chemical substance | 3 | 34 | 131 | 6663 | 2.9E-02 | AKR1C1; CCL20; NQO1 |
electron transport | 4 | 34 | 231 | 6663 | 2.9E-02 | NQO1; OKL38; TXNRD1; UGDH |
regulation of cell migration | 1 | 34 | 6 | 6663 | 3.0E-02 | JAG1 |
glycosaminoglycan biosynthesis | 1 | 34 | 6 | 6663 | 3.0E-02 | UGDH |
regulation of DNA replication | 1 | 34 | 7 | 6663 | 3.5E-02 | PCNA |
N signaling pathway | 1 | 34 | 7 | 6663 | 3.5E-02 | JAG1 |
heavy metal sensitivity/resistance | 1 | 34 | 7 | 6663 | 3.5E-02 | TXNRD1 |
nerve-nerve synaptic transmission | 1 | 34 | 7 | 6663 | 3.5E-02 | NQO1 |
aminoglycan biosynthesis | 1 | 34 | 7 | 6663 | 3.5E-02 | UGDH |
glutathione biosynthesis | 1 | 34 | 7 | 6663 | 3.5E-02 | GCLM |
regulation of apoptosis | 3 | 34 | 149 | 6663 | 4.0E-02 | BIRC5; CDKN1A; IER3 |
glutathione metabolism | 1 | 34 | 8 | 6663 | 4.0E-02 | GCLM |
nucleotide-sugar metabolism | 1 | 34 | 8 | 6663 | 4.0E-02 | UGDH |
negative regulation of apoptosis | 2 | 34 | 67 | 6663 | 4.5E-02 | BIRC5; IER3 |
anti-apoptosis | 2 | 34 | 67 | 6663 | 4.5E-02 | BIRC5; IER3 |
carboxylic acid metabolism | 4 | 34 | 270 | 6663 | 4.7E-02 | AKR1C3; GCLM; MGST1; UGDH |
organic acid metabolism | 4 | 34 | 271 | 6663 | 4.8E-02 | AKR1C3; GCLM; MGST1; UGDH |
lipoprotein metabolism | 1 | 34 | 10 | 6663 | 5.0E-02 | APOC1 |
nitric oxide metabolism | 1 | 34 | 10 | 6663 | 5.0E-02 | NQO1 |
nitric oxide biosynthesis | 1 | 34 | 10 | 6663 | 5.0E-02 | NQO1 |